Compare StocksADBE vs VRTX

Adobe Inc. (ADBE) vs Vertex Pharmaceuticals Incorporated (VRTX): Which Is the Better Buy in 2026?

As of 2026-06-19, ADBE is undervalued at $195, with a DCF intrinsic value of $558 and a margin of safety of 65%. VRTX is fairly valued at $452, with an intrinsic value of $454 and a margin of safety of 0%. Of the two, ADBE has the wider margin of safety.

ADBE
Adobe Inc.
$195.16
VS
VRTX
Vertex Pharmaceuticals Incorporated
$451.63

Rewards

ADBE
  • Adobe Inc. has maintained ROIC above 15% for 4 consecutive years, indicating a durable competitive advantage.
  • Gross margin of 89.4% indicates strong pricing power — typical of businesses with significant intellectual property or brand strength.
  • Adobe Inc. scores 100/100 on the Economic Moat Score (Wide Moat), with roic consistency as the strongest competitive dimension.
VRTX
  • Altman Z-Score of 12.04 indicates very low bankruptcy risk — the company is firmly in the safe zone.
  • Net debt/EBITDA of -1.1x means the company holds more cash than debt — a net cash position.

Risks

ADBE
    VRTX
    • FCF yield of 2.4% is below 3%, meaning the market is pricing in substantial future growth to justify the current price.
    • 10 insider sales totaling $7.9M with no purchases in the past 3 months — insiders are reducing their exposure.
    • Free cash flow has declined at a 6.6% CAGR over the past 4 years — a concerning trend.

    Key Valuation Metrics

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    ADBE
    VRTX
    Valuation
    $9.22B
    Free Cash Flow
    $2.78B
    11.88%
    FCF Yield
    2.43%
    11.16
    Trailing P/E
    26.79
    7.09
    Forward P/E
    21.03
    Quality & Moat
    37.82%
    ROIC
    17.24%
    62.95%
    ROE
    24.20%
    89.40%
    Gross Margin
    54.39%
    0.57
    PEG Ratio
    1.70
    Balance Sheet Safety
    0.13
    Net Debt / Equity
    Net cash
    N/A
    Interest Coverage
    N/A
    0.15
    Net Debt / EBITDA
    -1.06
    0.00%
    Dividend Yield
    0.00%
    ADBE: 8Ties: 1VRTX: 3
    ADBEVRTX

    Historical Fundamentals

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    ADBE

    Price ÷ Earnings Per Share — how many years of current earnings you're paying for at today's price. Lower P/E may indicate undervaluation. The dashed forward point is the forward P/E — today's price ÷ analyst consensus EPS.

    VRTX

    Price ÷ Earnings Per Share — how many years of current earnings you're paying for at today's price. Lower P/E may indicate undervaluation. The dashed forward point is the forward P/E — today's price ÷ analyst consensus EPS.

    Price ÷ Earnings Per Share — how many years of current earnings you're paying for at today's price. Lower P/E may indicate undervaluation. The dashed forward point is the forward P/E — today's price ÷ analyst consensus EPS.

    $1 Retained Earnings Test

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    ADBE
    $-0.60
    created per $1 retained over 3 years
    Market Cap Declined
    Σ Retained
    $18.12B
    Δ Market Cap
    $-10.93B
    Buffett's "$1 Test": For every $1 of earnings retained, has management created at least $1 of market value?
    > $1 created per $1 retained = Value Creator · < $1 created = Value Destroyer
    VRTX
    $5.82
    created per $1 retained over 3 years
    Exceptional Value Creator
    Σ Retained
    $7.04B
    Δ Market Cap
    +$40.93B
    Buffett's "$1 Test": For every $1 of earnings retained, has management created at least $1 of market value?
    > $1 created per $1 retained = Value Creator · < $1 created = Value Destroyer

    Buffett's "$1 Test": For every $1 of earnings retained, has management created at least $1 of market value?
    > $1 created per $1 retained = Value Creator · < $1 created = Value Destroyer

    Discounted Cash Flow (DCF) Analysis

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    ADBE
    65.0% Margin of Safety
    Price is 65.0% below estimated fair value
    Current Price: $195.16
    Fair Value: $558.28
    Strongly undervalued
    Undervalued
    Fairly valued
    Overvalued
    Strongly overvalued
    VRTX
    0.4% Margin of Safety
    Price is 0.4% below estimated fair value
    Current Price: $451.63
    Fair Value: $453.56
    Strongly undervalued
    Undervalued
    Fairly valued
    Overvalued
    Strongly overvalued

    Reverse DCF — Market-Implied Growth

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    ADBE

    What growth rate is the market pricing in at $195?

    -1.6%
    Market-Implied Owner Earnings Growth
    Standard FCF implies -4.0%

    The market implies -1.6% Owner Earnings growth, below historical trends — potential opportunity.

    Standard FCF implies a more demanding -4.0%, reflecting heavy growth investment expected to generate future returns.

    VRTX

    What growth rate is the market pricing in at $452?

    +12.1%
    Market-Implied Owner Earnings Growth
    Standard FCF implies +16.9%

    The market implies +12.1% Owner Earnings growth, above historical trends.

    Standard FCF implies a demanding +16.9%, reflecting heavy growth investment.

    Economic Moat Score

    Learn more →
    ADBE
    100/100
    Wide Moat
    70+ Wide · 40-69 Narrow · <40 None

    Wide moat with strength across all dimensions. ROIC Consistency is the standout factor.

    Composite score measuring competitive advantage durability across four dimensions: returns above cost of capital, pricing power stability, revenue predictability, and capital efficiency. Based on 4 years of fundamental data.
    VRTX
    65/100
    Narrow Moat
    70+ Wide · 40-69 Narrow · <40 None

    Narrow moat with revenue predictability as the key competitive advantage. Improving margin stability would strengthen the moat.

    Composite score measuring competitive advantage durability across four dimensions: returns above cost of capital, pricing power stability, revenue predictability, and capital efficiency. Based on 4 years of fundamental data.

    Forensic Accounting

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    ADBE
    -2.85
    Unlikely Manipulator
    Above -1.78 = likely manipulator · -2.22 to -1.78 = grey zone

    M-Score Trend

    Beneish's 8-variable model estimates the probability of earnings manipulation. An M-Score above -1.78 signals elevated risk — companies in this range have historically been 3-5× more likely to be manipulating earnings. Scores between -2.22 and -1.78 fall in a grey zone warranting further investigation.
    VRTX
    -2.06
    Possible Manipulator
    Above -1.78 = likely manipulator · -2.22 to -1.78 = grey zone
    Beneish's 8-variable model estimates the probability of earnings manipulation. An M-Score above -1.78 signals elevated risk — companies in this range have historically been 3-5× more likely to be manipulating earnings. Scores between -2.22 and -1.78 fall in a grey zone warranting further investigation.

    Beneish's 8-variable model estimates the probability of earnings manipulation. An M-Score above -1.78 signals elevated risk — companies in this range have historically been 3-5× more likely to be manipulating earnings. Scores between -2.22 and -1.78 fall in a grey zone warranting further investigation.

    Ownership Breakdown

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    ADBE
    Insiders 0.2%Institutions 88.1%Retail & Other 11.7%
    No. of Institutional Holders3,191
    High insider ownership aligns management incentives with shareholders — a key signal in Buffett-style analysis. Institutional concentration can indicate smart-money conviction but also crowding risk.
    VRTX
    Insiders 0.2%Institutions 98.0%Retail & Other 1.8%
    No. of Institutional Holders2,369
    High insider ownership aligns management incentives with shareholders — a key signal in Buffett-style analysis. Institutional concentration can indicate smart-money conviction but also crowding risk.

    High insider ownership aligns management incentives with shareholders. Institutional concentration can indicate smart-money conviction but also crowding risk.

    Insider Buying Activity

    Learn more →
    ADBE
    0
    Buys (3M)
    0
    Buys (12M)
    DURN DANIEL J
    Chief Financial Officer
    $507,758
    @ $390.58 · 2025-03-20
    RICKS DAVID A
    Director
    $998,946
    @ $443.98 · 2025-01-28
    Open market purchases · includes direct & indirect ownership · excludes option exercises
    VRTX
    0
    Buys (3M)
    2
    Buys (12M)
    Total value (12M): $5.84M
    KEWALRAMANI RESHMA
    Chief Executive Officer
    $3.90M
    @ $389.58 · 2025-08-06
    SACHS BRUCE I
    Director
    $1.95M
    @ $389.68 · 2025-08-06
    Open market purchases · includes direct & indirect ownership · excludes option exercises

    Open market purchases · includes direct & indirect ownership · excludes option exercises.

    Insider Selling Activity

    Learn more →
    ADBE
    2
    Sells (3M)
    4
    Sells (12M)
    Total value (12M): $1.05M
    FORUSZ JILLIAN
    Officer
    $185,915
    @ $246.25 · 2026-04-30
    DURN DANIEL J
    Chief Financial Officer
    $331,355
    @ $248.02 · 2026-04-20
    DURN DANIEL J
    Chief Financial Officer
    $485,323
    @ $294.85 · 2026-01-27
    FORUSZ JILLIAN
    Officer
    $50,344
    @ $337.88 · 2025-10-31
    FORUSZ JILLIAN
    Officer
    $175,828
    @ $380.58 · 2025-05-02
    FORUSZ JILLIAN
    Officer
    $145,567
    @ $435.83 · 2025-01-28
    BELSKY SCOTT K
    Officer
    $2.05M
    @ $431.61 · 2025-01-27
    BANSE AMY L
    Director
    $333,300
    @ $550.00 · 2024-12-06
    FORUSZ JILLIAN
    Officer
    $327,987
    @ $485.19 · 2024-10-29
    BELSKY SCOTT K
    Officer
    $232,525
    @ $483.42 · 2024-10-25
    BELSKY SCOTT K
    Officer
    $1.14M
    @ $511.48 · 2024-10-16
    DURN DANIEL J
    Chief Financial Officer
    $3.35M
    @ $515.44 · 2024-09-17
    GARFIELD MARK S.
    Officer
    $52,089
    @ $537.00 · 2024-07-25
    BELSKY SCOTT K
    Officer
    $258,297
    @ $537.00 · 2024-07-25
    GARFIELD MARK S.
    Officer
    $85,255
    @ $564.60 · 2024-07-16
    BELSKY SCOTT K
    Officer
    $1.25M
    @ $561.60 · 2024-07-16
    Direct ownership only · excludes indirect, option exercises, planned (10b5-1) sales & derivatives
    VRTX
    10
    Sells (3M)
    48
    Sells (12M)
    Total value (12M): $153.89M
    BOZIC CARMEN
    Officer
    $785,250
    @ $450.00 · 2026-06-05
    LIU JOY
    Officer
    $364,245
    @ $439.91 · 2026-06-01
    BOZIC CARMEN
    Officer
    $888,300
    @ $450.00 · 2026-05-29
    BUNNAGE MARK E.
    Officer
    $14,964
    @ $453.45 · 2026-05-15
    BOZIC CARMEN
    Officer
    $613,971
    @ $453.45 · 2026-05-15
    BOZIC CARMEN
    Officer
    $3.14M
    @ $450.00 · 2026-05-12
    BHATIA SANGEETA N
    Director
    $134,746
    @ $423.73 · 2026-05-04
    LIU JOY
    Officer
    $469,222
    @ $425.02 · 2026-05-01
    LIU JOY
    Officer
    $439,288
    @ $449.17 · 2026-04-01
    BOZIC CARMEN
    Officer
    $1.05M
    @ $450.95 · 2026-03-27
    BOZIC CARMEN
    Officer
    $1.12M
    @ $481.79 · 2026-03-13
    MCKECHNIE DUNCAN
    Officer
    $1.31M
    @ $498.42 · 2026-03-11
    MCKECHNIE DUNCAN
    Officer
    $1.16M
    @ $475.30 · 2026-03-04
    LIU JOY
    Officer
    $442,396
    @ $495.96 · 2026-03-02
    BOZIC CARMEN
    Officer
    $1.12M
    @ $480.31 · 2026-02-27
    KEWALRAMANI RESHMA
    Chief Executive Officer
    $19.74M
    @ $493.47 · 2026-02-27
    AMBROSE KRISTEN
    Officer
    $172,560
    @ $483.36 · 2026-02-26
    ATKINSON EDWARD MORROW III
    Chief Technology Officer
    $324,882
    @ $486.35 · 2026-02-25
    MCKECHNIE DUNCAN
    Officer
    $2.39M
    @ $487.65 · 2026-02-25
    BUNNAGE MARK E.
    Officer
    $301,537
    @ $486.35 · 2026-02-25
    TATSIS OURANIA
    Officer
    $126,451
    @ $486.35 · 2026-02-25
    BILLER JONATHAN PRIM
    Officer
    $459,601
    @ $486.35 · 2026-02-25
    AMBROSE KRISTEN
    Officer
    $108,456
    @ $486.35 · 2026-02-25
    SACHDEV AMIT
    Officer
    $897,802
    @ $486.35 · 2026-02-25
    SACHDEV AMIT
    Officer
    $27.48M
    @ $468.83 · 2026-02-19
    ATKINSON EDWARD MORROW III
    Chief Technology Officer
    $1.38M
    @ $484.93 · 2026-02-18
    BUNNAGE MARK E.
    Officer
    $1.75M
    @ $484.31 · 2026-02-18
    TATSIS OURANIA
    Officer
    $472,395
    @ $483.52 · 2026-02-18
    BILLER JONATHAN PRIM
    Officer
    $1.80M
    @ $484.18 · 2026-02-18
    AMBROSE KRISTEN
    Officer
    $1.06M
    @ $484.87 · 2026-02-18
    TATSIS OURANIA
    Officer
    $749,985
    @ $499.99 · 2026-02-13
    BILLER JONATHAN PRIM
    Officer
    $493,012
    @ $499.00 · 2026-02-13
    BHATIA SANGEETA N
    Director
    $133,000
    @ $500.00 · 2026-02-13
    ATKINSON EDWARD MORROW III
    Chief Technology Officer
    $806,213
    @ $460.43 · 2026-02-11
    BUNNAGE MARK E.
    Officer
    $930,529
    @ $460.43 · 2026-02-11
    TATSIS OURANIA
    Officer
    $214,560
    @ $460.43 · 2026-02-11
    BILLER JONATHAN PRIM
    Officer
    $886,328
    @ $460.43 · 2026-02-11
    AMBROSE KRISTEN
    Officer
    $633,552
    @ $460.43 · 2026-02-11
    TATSIS OURANIA
    Officer
    $2.14M
    @ $474.99 · 2026-01-07
    WAGNER CHARLES F JR
    Chief Operating Officer
    $4.39M
    @ $461.00 · 2026-01-06
    TATSIS OURANIA
    Officer
    $2.02M
    @ $449.99 · 2025-12-03
    BILLER JONATHAN PRIM
    Officer
    $155,803
    @ $449.00 · 2025-12-03
    WAGNER CHARLES F JR
    Chief Operating Officer
    $6.38M
    @ $456.00 · 2025-12-03
    LEIDEN JEFFREY M
    Officer and Director
    $28.65M
    @ $449.20 · 2025-12-03
    ATKINSON EDWARD MORROW III
    Chief Technology Officer
    $1.09M
    @ $434.58 · 2025-11-17
    LEIDEN JEFFREY M
    Officer and Director
    $32.29M
    @ $440.60 · 2025-11-14
    BILLER JONATHAN PRIM
    Officer
    $280,522
    @ $404.21 · 2025-10-02
    BHATIA SANGEETA N
    Director
    $102,860
    @ $386.69 · 2025-08-27
    ALTSHULER DAVID
    Officer
    $22,084
    @ $424.69 · 2025-05-15
    BHATIA SANGEETA N
    Director
    $202,344
    @ $505.86 · 2025-05-02
    ALTSHULER DAVID
    Officer
    $1.65M
    @ $510.00 · 2025-03-13
    TATSIS OURANIA
    Officer
    $1.62M
    @ $499.99 · 2025-03-10
    ALTSHULER DAVID
    Officer
    $1.62M
    @ $500.00 · 2025-03-10
    WAGNER CHARLES F JR
    Chief Financial Officer
    $1.65M
    @ $500.00 · 2025-03-10
    TATSIS OURANIA
    Officer
    $1.97M
    @ $485.49 · 2025-03-04
    ALTSHULER DAVID
    Officer
    $1.58M
    @ $490.00 · 2025-03-03
    ATKINSON EDWARD MORROW III
    Chief Technology Officer
    $1.26M
    @ $475.34 · 2025-02-27
    TATSIS OURANIA
    Officer
    $251,930
    @ $475.34 · 2025-02-27
    ALTSHULER DAVID
    Officer
    $610,560
    @ $480.00 · 2025-02-27
    ATKINSON EDWARD MORROW III
    Officer
    $849,839
    @ $480.95 · 2025-02-25
    TATSIS OURANIA
    Officer
    $170,256
    @ $480.95 · 2025-02-25
    AMBROSE KRISTEN
    Officer
    $425,160
    @ $480.95 · 2025-02-25
    ALTSHULER DAVID
    Officer
    $407,846
    @ $480.95 · 2025-02-25
    ALTSHULER DAVID
    Officer
    $533,280
    @ $480.00 · 2025-02-20
    TATSIS OURANIA
    Officer
    $111,035
    @ $455.06 · 2025-02-18
    BILLER JONATHAN PRIM
    Officer
    $754,034
    @ $455.06 · 2025-02-18
    AMBROSE KRISTEN
    Officer
    $305,345
    @ $455.06 · 2025-02-18
    ATKINSON EDWARD MORROW III
    Chief Technology Officer
    $803,323
    @ $459.83 · 2025-02-11
    TATSIS OURANIA
    Officer
    $142,547
    @ $459.83 · 2025-02-11
    BILLER JONATHAN PRIM
    Officer
    $1.58M
    @ $459.87 · 2025-02-11
    AMBROSE KRISTEN
    Officer
    $632,726
    @ $459.83 · 2025-02-11
    ALTSHULER DAVID
    Officer
    $7,178
    @ $478.53 · 2024-11-15
    WAGNER CHARLES F JR
    Chief Financial Officer
    $1.55M
    @ $518.27 · 2024-11-11
    KEWALRAMANI RESHMA
    Chief Executive Officer
    $7.83M
    @ $515.00 · 2024-11-08
    BILLER JONATHAN PRIM
    Officer
    $461,198
    @ $461.66 · 2024-10-02
    BHATIA SANGEETA N
    Director
    $323,000
    @ $500.00 · 2024-08-30
    LEIDEN JEFFREY M
    Officer and Director
    $1.89M
    @ $499.00 · 2024-08-30
    BHATIA SANGEETA N
    Director
    $602,447
    @ $466.29 · 2024-08-08
    BOZIC CARMEN
    Officer
    $1.09M
    @ $476.75 · 2024-08-07
    SACHS BRUCE I
    Director
    $2.69M
    @ $508.00 · 2024-08-01
    KEWALRAMANI RESHMA
    Chief Executive Officer
    $7.68M
    @ $505.00 · 2024-07-30
    BOZIC CARMEN
    Officer
    $1.11M
    @ $488.46 · 2024-07-24
    KEWALRAMANI RESHMA
    Chief Executive Officer
    $7.56M
    @ $497.00 · 2024-07-22
    BOZIC CARMEN
    Officer
    $1.11M
    @ $487.34 · 2024-07-10
    BOZIC CARMEN
    Officer
    $1.08M
    @ $471.72 · 2024-06-26
    Direct ownership only · excludes indirect, option exercises, planned (10b5-1) sales & derivatives

    Direct ownership only · excludes indirect, option exercises, planned (10b5-1) sales & derivatives.

    🎭 Mr. Market's Mood

    Learn more →
    ADBE
    FearGreed
    🥶Extreme Fear(17/100)

    "Mr. Market is panicking — potential buying opportunity if fundamentals are strong"

    Composite sentiment score based on 6 market signals. Inspired by Buffett's "Mr. Market" allegory — fear = potential opportunity, greed = potential risk. Must be used alongside fundamental analysis, not in isolation.
    VRTX
    FearGreed
    😐Neutral(57/100)

    "Market is pricing this stock without strong emotion in either direction"

    Composite sentiment score based on 6 market signals. Inspired by Buffett's "Mr. Market" allegory — fear = potential opportunity, greed = potential risk. Must be used alongside fundamental analysis, not in isolation.

    Composite sentiment score based on market signals. Inspired by Buffett’s "Mr. Market" allegory — fear = potential opportunity, greed = potential risk. Must be used alongside fundamental analysis, not in isolation.

    ⚖️ Buffett Signal

    Learn more →
    ADBE
    Awaiting DCF Data

    The Buffett Signal cross-references market sentiment with DCF valuation. Configure the DCF Analysis above to generate a signal.

    DCF Margin of Safety: N/AMr. Market's Mood: Extreme Fear (17)
    VRTX
    Awaiting DCF Data

    The Buffett Signal cross-references market sentiment with DCF valuation. Configure the DCF Analysis above to generate a signal.

    DCF Margin of Safety: N/AMr. Market's Mood: Neutral (57)
    View ADBE Full AnalysisView VRTX Full Analysis

    Frequently Asked Questions: ADBE vs VRTX

    Is Adobe Inc. or Vertex Pharmaceuticals Incorporated more undervalued in 2026?

    Based on our discounted cash flow model, ADBE trades at a 65.0% margin of safety (intrinsic value $558 vs. price $195), compared to VRTX's 0.4% margin of safety (intrinsic $454 vs. $452).

    Which stock has a wider economic moat, Adobe Inc. or Vertex Pharmaceuticals Incorporated?

    ADBE scores 100/100 (Wide moat), while VRTX scores 65/100 (Narrow moat). The moat score measures competitive advantage durability across ROIC consistency, margin stability, revenue predictability, and reinvestment efficiency.

    Which company has better free cash flow, Adobe Inc. or Vertex Pharmaceuticals Incorporated?

    Adobe Inc. (ADBE) generates a 11.9% free cash flow yield, compared to Vertex Pharmaceuticals Incorporated's 2.4%. A higher FCF yield means the business converts more of its market value into cash that can be returned to shareholders or reinvested.

    Which stock has higher return on invested capital, Adobe Inc. or Vertex Pharmaceuticals Incorporated?

    ADBE earns 37.8% ROIC versus VRTX's 17.2%. A higher ROIC means the company generates more profit per dollar of capital employed, a hallmark of durable competitive advantage in Buffett-style analysis.